کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10160388 | 75 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Self-assembling and auto-crosslinkable hyaluronic acid hydrogels with a fibrillar structure
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موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
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چکیده انگلیسی
A hyaluronic acid derivative bearing pendant l-benzoyl-cysteine portions (with a derivatization degree equal to 10Â mol.%) was synthesized by linking N,Nâ²-dibenzoyl-l-cystine to the polysaccharide and then reducing its disulfide bridge to thiol groups. The formation of Ï-Ï stacking interactions between the benzoyl moieties was studied by fluorescence spectroscopy as a function of polymer concentration and oxidation time. The efficiency of oxidation of thiol groups to disulfide bridges occurring in phosphate buffer pH 7.4, was determined by colorimetric assays. The hydrogel formed by means of oxidative crosslinking has shown the presence of fibrillar aggregates as detected by light and scanning electron microscopy. Human derm fibroblasts were encapsulated into hydrogel-forming solution, and their ability to proliferate was tested during 3Â days of culture.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Biomaterialia - Volume 6, Issue 1, January 2010, Pages 195-204
Journal: Acta Biomaterialia - Volume 6, Issue 1, January 2010, Pages 195-204
نویسندگان
F.S. Palumbo, G. Pitarresi, A. Albanese, F. Calascibetta, G. Giammona,