کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10165611 | 1180244 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nonsteroidal Anti-inflammatory Drugs, Proton Pump Inhibitors, and Gastrointestinal Injury: Contrasting Interactions in the Stomach and Small Intestine
ترجمه فارسی عنوان
داروهای ضد التهابی غیر استروئیدی، مهارکننده های پروتون پمپ و آسیب های دستگاه گوارش: تعاملات متقابل در معده و روده کوچک
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کلمات کلیدی
ASANSAIDPPIIBDIBSSIBONAFLDacetylsalicylic acid - استیل اسلسیلیک اسیدsmall intestinal bacterial overgrowth - بیش از حد باکتریایی روده کوچکNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیInflammatory bowel disease - بیماریهای التهابی رودهnonsteroidal anti-inflammatory drug - داروهای ضد التهابی غیر استروئیدیGastrointestinal - دستگاه گوارشirritable bowel syndrome - سندروم روده تحریک پذیر، کولیت عصبیProton pump inhibitor - مهار کننده پمپ پروتونcapsule endoscopy - کپسول آندوسکوپی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
کاردیولوژی و پزشکی قلب و عروق
چکیده انگلیسی
Nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) are among the most frequently prescribed groups of drugs worldwide. The use of NSAIDs is associated with a high number of significant adverse effects. Recently, the safety of PPIs has also been challenged. Capsule endoscopy studies reveal that even low-dose NSAIDs are responsible for gut mucosal injury and numerous clinical adverse effects, for example, bleeding and anemia, that might be difficult to diagnose. The frequent use of PPIs can exacerbate NSAID-induced small intestinal injury by altering intestinal microbiota. Thus, the use of PPI is considered to be an independent risk factor associated with NSAID-associated enteropathy. In this review, we discuss this important clinical problem and review relevant aspects of epidemiology, pathophysiology, and management. We also present the hypothesis that even minor and subclinical injury to the intestinal mucosa can result in significant, though delayed, metabolic consequences, which may seriously affect the health of an individual. PubMed was searched using the following key words (each key word alone and in combination): gut microbiota, microbiome, non-steroidal anti inflammatory drugs, proton pump inhibitors, enteropathy, probiotic, antibiotic, mucosal injury, enteroscopy, and capsule endoscopy. Google engine search was also carried out to identify additional relevant articles. Both original and review articles published in English were reviewed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mayo Clinic Proceedings - Volume 89, Issue 12, December 2014, Pages 1699-1709
Journal: Mayo Clinic Proceedings - Volume 89, Issue 12, December 2014, Pages 1699-1709
نویسندگان
Wojciech MD, PhD, Igor MD, PhD, David S. MD, FRCP, Eamonn M. MD, FRCP, FACP, FACG, FRCPI,