Changes in synovial fluid and serum concentrations of cartilage oligomeric matrix protein over 5Â years after anterior cruciate ligament rupture: an exploratory analysis in the KANON trial

The local process after an acute ACL injury generates increased SF COMP concentrations in the injured knee up to 5 years after injury. This response is not detected in serum. Discrepancies in associations between sCOMP measured by BioVendor and AnaMar immunoassays with other biomarkers indicate differences in detected COMP fragments.