کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10223173 | 1701011 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Role of Sex in Sleep Deprivation Related Changes of Nociception and Conditioned Pain Modulation
ترجمه فارسی عنوان
نقش جنسیت در تغییرات مربوط به محرومیت از خواب و عدم مداخله درد دلبند
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کلمات کلیدی
S.E.MCDTState and Trait Anxiety InventoryWDTPHSBDIMDTendogenous pain controlTSDMPTIMIVDThptTSLWURPPTCPMCPTDMAqst - QSTCold pressor test - آزمایشی سرد مطبوعاتcold detection threshold - آستانه تشخیص سرماVibration detection threshold - آستانه تشخیص لرزشmechanical detection threshold - آستانه تشخیص مکانیکیwarm detection threshold - آستانه تشخیص گرمcold pain threshold - آستانه درد سردMechanical pain threshold - آستانه درد مکانیکیHeat pain threshold - آستانه درد گرماNociceptive thresholds - آستانه های ناسازگارDynamic mechanical allodynia - آلدینیا مکانیکی دینامیکیinnovative medicines initiative - ابتکارات داروهای ابتکاریstandard deviation - انحراف معیارQuantitative Sensory Testing - تست حساسیت کمیSex - جنسیت، رابطه ی جنسیMechanical pain sensitivity - حساسیت درد مکانیکیstandard error of the mean - خطای استاندارد میانگینthermal sensory limen - درجه حرارت حسیSTAI - شماpressure pain threshold - فشار آستانه دردSleep deprivation - محرومیت از خوابTotal sleep deprivation - محرومیت از خواب کاملconditioned pain modulation - مدولاسیون درد ناشی از مشکالتMPs - نمایندگان مجلسBeck Depression Inventory - پرسشنامه افسردگی بک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
Sex matters both in the clinical field of pain and sleep medicine. Sleep disturbances are highly prevalent in chronic pain patients and have been shown to deteriorate the pain condition. The pathomechanisms by which insomnia aggravates pain are currently unknown. Descending pain control may be compromised by disturbed sleep, but respective studies are few, inconsistent and largely imbalanced with respect to sex. We studied the role of sex on the effect of sleep deprivation on endogenous pain modulation and on nociceptive thresholds in a highly homogenous study population of 18 female (23.8â¯Â±â¯3.4â¯years) and 18 male (23.3â¯Â±â¯2.7) healthy students. One night of total sleep deprivation (TSD) was contrasted with one night of habitual sleep in a balanced cross-over design. A cold pressor test was used to explore the effect of TSD on supraspinal pain control. The effect of TSD on nociception was examined by Quantitative Sensory Testing (QST). RM-ANOVA was used for statistical analysis. We found a sex-dependent effect of TSD on descending pain pathways, since the endogenous capacity to inhibit pain was only reduced in sleep deprived females (interaction between 'sleep condition' and 'sex': pâ¯=â¯0.023). While TSD-induced cold and mechanical hyperalgesia were independent of sex, heat pain thresholds did only significantly decrease in sleep deprived females (pâ¯=â¯0.041). Our results point to a sex specific impact of TSD on descending pain inhibition. In the future, therapeutic strategies for pain patients with co-morbid insomnia may need to more explicitly respect the specific role of sex.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 387, 1 September 2018, Pages 191-200
Journal: Neuroscience - Volume 387, 1 September 2018, Pages 191-200
نویسندگان
Nicole Eichhorn, Rolf-Detlef Treede, Sigrid Schuh-Hofer,