کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10229618 | 546 | 2011 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Currently, nanomaterials (NMs) with particle sizes below 100Â nm have been successfully employed in various industrial applications in medicine, cosmetics and foods. On the other hand, NMs can also be problematic in terms of eliciting a toxicological effect by their small size. However, biological and/or cellular responses to NMs are often inconsistent and even contradictory. In addition, relationships among NMs physicochemical properties, absorbency, localization and biological responses are not yet well understood. In order to open new frontiers in medical, cosmetics and foods fields by the safer NMs, it is necessary to collect the information of the detailed properties of NMs and then, build the prediction system of NMs safety. The present study was designed to examine the skin penetration, cellular localization, and cytotoxic effects of the well-dispersed amorphous silica particles of diameters ranging from 70Â nm to 1000Â nm. Our results suggested that the well-dispersed amorphous nanosilica of particle size 70Â nm (nSP70) penetrated the skin barrier and caused systemic exposure in mouse, and induced mutagenic activity in vitro. Our information indicated that further studies of relation between physicochemical properties and biological responses are needed for the development and the safer form of NMs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomaterials - Volume 32, Issue 11, April 2011, Pages 2713-2724
Journal: Biomaterials - Volume 32, Issue 11, April 2011, Pages 2713-2724
نویسندگان
Hiromi Nabeshi, Tomoaki Yoshikawa, Keigo Matsuyama, Yasutaro Nakazato, Kazuhiko Matsuo, Akihiro Arimori, Masaaki Isobe, Saeko Tochigi, Sayuri Kondoh, Toshiro Hirai, Takanori Akase, Takuya Yamashita, Kohei Yamashita, Tokuyuki Yoshida, Kazuya Nagano,