Comparison of various culture modes for the production of rabies virus by Vero cells grown on microcarriers in a 2-l bioreactor

We then evaluated rabies virus production by Vero cells grown on 3 g/l of Cytodex 1 using recirculation culture mode during the growth phase. Cells were infected at the optimal conditions previously determined. The maximal virus titer was equal to 2 × 107 FFU/ml. The activity of the experimental vaccine prepared showed a protective activity that meets WHO requirements.