کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10233246 42737 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A way for resolution of (R, S)-2-octanol by combining dynamic kinetic resolution with double kinetic resolution
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
پیش نمایش صفحه اول مقاله
A way for resolution of (R, S)-2-octanol by combining dynamic kinetic resolution with double kinetic resolution
چکیده انگلیسی
Although the enantioselectivity of the Pseudomonas cp. lipase (PCL) used in the kinetic resolution of (R, S)-2-octanol is moderate, the (S)-enantiomer 2 with 98% ee and (R)-enantiomer 6 with 95% ee can be obtained by combining dynamic kinetic resolution (DyKR) with double kinetic resolution (DoKR) and 80% racemic substrate can be converted to enantiopure products by the way. The method is based on the feasibility of using the residue of one DoKR as the substrate of the next DoKR and so on recycling them to DyKR. The strategy is adapted to large-scale resolution of common sec-alcohols, especially to which when the moderate enantioselective lipases can be employed.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Enzyme and Microbial Technology - Volume 36, Issue 4, 2 March 2005, Pages 595-599
نویسندگان
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