Involvement of the AtoSCDAEB regulon in the high molecular weight poly-(R)-3-hydroxybutyrate biosynthesis in phaCAB+Escherichia coli

► AtoSC system up-regulates the PHB biosynthesis, in recombinant phaCABC.nec.+E. coli. ► AtoSC regulates PHB through atoDAEB operon and additional biochemical mechanisms. ► Interplay between fatty-acid metabolism and AtoSCDAEB regulon takes place for PHB biosynthesis.