A laccase with anti-proliferative activity against tumor cells from a white root fungus Abortiporus biennis

► We report a laccase from genus Abortiporus for the first time. ► We evaluate its physical, chemical, and bioactive properties. ► It manifests sequence similarity with Polyporaceae laccases, but different from others. ► It shows unique properties different from Polyporaceae laccases. ► It possesses inhibitory activity toward tumor cell and HIV-1 RT.