Transfer of tetracyclines across the H2O|1,2-dichloroethane interface: Analysis of degraded products in strong acid and alkaline solutions

The charge transfer processes for tetracycline and tetracycline derivatives are characterized across the H2O|1,2-dicloroethane interface. Stability of tetracycline and tetracycline derivatives, TC, OTC, and ClTC is studied in strong acid and alkaline solutions. The analysis of the degraded solutions is carried out with cyclic voltammetry applied to the H2O|1,2-dicloroethane interface and the results obtained are complemented with measures of UV-vis spectroscopy in the homogeneous phase.