کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10275727 | 463387 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direct electrochemical acetoxylation of cholesterol at the allylic position
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
مهندسی شیمی (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Direct electrochemical acetoxylation of cholesterol at the allylic position Direct electrochemical acetoxylation of cholesterol at the allylic position](/preview/png/10275727.png)
چکیده انگلیسی
It has been found that cholesterol undergoes direct electrochemical oxidation on platinum electrode in glacial acetic acid containing sodium perchlorate and sodium acetate as supporting electrolytes. Voltammetric measurements show that the process is controlled by the rate of electron transfer and the height of the oxidation peak is linear vs. concentration of cholesterol. Preparative electrolysis afforded two major products: 7α-acetoxycholesterol and 7β-acetoxycholesterol in the ratio 10:3, as established by integration of the C-6 proton signals in the 1H NMR spectrum. The same products were obtained when sodium acetate was replaced by sodium trifluoroacetate but stereoselectivity was lost (product ratio 1:1) at that time. Easy thermal elimination of acetic acid from the products may be potentially used for the synthesis of 7-dehydrocholesterol (provitamin D3).
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Electroanalytical Chemistry - Volume 585, Issue 2, 15 November 2005, Pages 275-280
Journal: Journal of Electroanalytical Chemistry - Volume 585, Issue 2, 15 November 2005, Pages 275-280
نویسندگان
Jan Kowalski, Jolanta PÅoszyÅska, Andrzej Sobkowiak, Jacek W. Morzycki, Agnieszka Z. Wilczewska,