Acute genistein treatment mimics the effects of estradiol by enhancing place learning and impairing response learning in young adult female rats

► Tested acute genistein effects on place and response learning in female rats ► Estradiol produced an inverted dose-response for enhancement of place learning. ► Genistein enhanced place learning but impaired response learning. ► Genistein treatment mimics estradiol-induced shifts in place and response learning.