The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats

► Ang II is involved in the pathogenesis of hypertension and regulation of reproduction. ► Hypertensive rats show inhibition of sexual behavior and spermatogenesis dysfunction. ► Losartan treatment prevents the changes in reproduction. ► Ang ll, acting through AT1 receptors, modulates reproductive function in hypertension.