کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10302820 | 543231 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abuse and diversion of buprenorphine sublingual tablets and film
ترجمه فارسی عنوان
سوءاستفاده و انحراف قرصهای دوبینی و قرص بوپرنورفین
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کلمات کلیدی
IRBREMSOpioid treatment programFDAOtp - OTPSubstance-related disorders - اختلالات مرتبط با موادUnited States Food and Drug Administration - اداره غذا و داروی ایالات متحدهRisk Evaluation and Mitigation Strategy - ارزیابی ریسک و کاهش استراتژیUnited States - ایالات متحده آمریکاSKIP - بروbuprenorphine - بوپرنورفینDrug abuse - سوء مصرف مواد95% confidence interval - فاصله اطمینان 95٪Drug formulations - فرمولاسیون داروinstitutional review board - هیئت بررسی نظارت
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Buprenorphine abuse is common worldwide. Rates of abuse and diversion of three sublingual buprenorphine formulations (single ingredient tablets; naloxone combination tablets and film) were compared. Data were obtained from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS®) System Poison Center, Drug Diversion, Opioid Treatment (OTP), Survey of Key Informants' Patients (SKIP), and College Survey Programs through December 2012. To control for drug availability, event ratios (rates) were calculated quarterly, based on the number of patients filling prescriptions for each formulation (“unique recipients of a dispensed drug,” URDD) and averaged and compared using negative binomial regression. Abuse rates in the OTP, SKIP, and College Survey Programs were greatest for single ingredient tablets, and abuse rates in the Poison Center Program and illicit diversion rates were greatest for the combination tablets. Combination film rates were significantly less than rates for either tablet formulation in all programs. No geographic pattern could be discerned.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Substance Abuse Treatment - Volume 47, Issue 1, July 2014, Pages 27-34
Journal: Journal of Substance Abuse Treatment - Volume 47, Issue 1, July 2014, Pages 27-34
نویسندگان
Eric J. M.D., S. Geoffrey Ph.D., Erin M. M.S., Becki Ph.D., Marie-Claire M.S., Jody L. Ph.D., Lenn E. MSPH, Ph.D., Theodore J. Ph.D., Steven P. Ph.D., Andrew Ph.D., Hilary L. Ph.D., Richard C. M.D., Ph.D.,