کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10304105 | 545664 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain
ترجمه فارسی عنوان
اثرات متفاوتی از درمان کوتاه مدت و طولانی مدت آنتی سایکوتیک بر بیان کننده گیرنده های نوروگولین-1 و ارب بی در مغز موش صحرایی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
چکیده انگلیسی
Neuregulin-1 (NRG1) and ErbB4 genes have been identified as candidate genes for schizophrenia. Post-mortem studies indicated that NRG1-ErbB4 signalling is impaired in schizophrenia subjects. This study investigated whether short- or long-term antipsychotic treatment has different effects on the expression of NRG1 and ErbB4 receptors. Female Sprague-Dawley rats were treated orally with either aripiprazole (0.75Â mg/kg), haloperidol (0.1Â mg/kg), olanzapine (0.5Â mg/kg), or vehicle, 3 times/day for 1 or 12 weeks. Western blotting was performed to examine the expression of NRG1 isoforms (135Â kDa, 70Â kDa and 40Â kDa) and ErbB4 receptors. Both 1-week haloperidol and olanzapine treatment increased NRG1-70Â kDa expression in the hippocampus; haloperidol also up-regulated ErbB4 levels in the prefrontal cortex (PFC). In the 12-week group, aripiprazole decreased the expression of all three NRG1 isoforms and ErbB4 receptors in the PFC, NRG1-70Â kDa and -40Â kDa in the cingulate cortex (Cg), and NRG1-135Â kDa, -70Â kDa and ErbB4 receptors in the hippocampus; haloperidol reduced NRG1-135Â kDa in the PFC, NRG1-40Â kDa in all three brain regions, and ErbB4 receptor levels in the PFC and hippocampus; NRG1-40Â kDa in the PFC and Cg was also down-regulated by olanzapine. These results suggest that the time-dependent and region-specific effects of antipsychotics on NRG1-ErbB4 signalling may contribute to the efficacy of antipsychotics to treat schizophrenia.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 225, Issue 3, 28 February 2015, Pages 347-354
Journal: Psychiatry Research - Volume 225, Issue 3, 28 February 2015, Pages 347-354
نویسندگان
Chao Deng, Bo Pan, Chang-Hua Hu, Mei Han, Xu-Feng Huang,