کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10306669 | 547416 | 2013 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute stress further decreases the effect of ovariectomy on immobility behavior and hippocampal cell survival in rats
ترجمه فارسی عنوان
استرس حاد، تاثیر تخریب بر رفتار بی حرکتی و بقای سلول هیپوکامپ در موش صحرایی را کاهش می دهد
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کلمات کلیدی
استرس حاد، آزمون اجباری شنا تکثیر سلولی، بقای سلولی، نوروژنز،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
چکیده انگلیسی
Most studies relating experimental depression and neurogenesis use mainly male rodents subjected to models of chronic stress. The forced swimming test (FST) is a widely utilized model of acute stress, but its effects on the neurogenic process in the hippocampus using females in different endocrine conditions has not been explored. The aim of this study was to evaluate the cell proliferation and early-, short- and long-lasting effects of forced swimming (FS) on adult hippocampal neurogenesis in rats in two endocrine conditions: proestrous and ovariectomized. To determine cell proliferation we used the endogenous marker Ki67. Cell survival was established with the thymidine analog, BrdU (75Â mg/kg, 2/12, i.p.), which was administered before FS to proestrous and ovariectomized rats. FS increased immobility and corticosterone levels in OVX but not in rats in proestrus. In addition, FS did not affect cell proliferation but significantly decreased the number of BrdU-labeled cells at 2Â h only in OVX-rats, an effect that remained for 3 and 14 days after FS. Data are discussed taking into consideration the relationship between gonadal and adrenal hormones in adult hippocampal neurogenesis in adult females. Our data also support the use of FS as a model for studying neurogenesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 38, Issue 8, August 2013, Pages 1407-1417
Journal: Psychoneuroendocrinology - Volume 38, Issue 8, August 2013, Pages 1407-1417
نویسندگان
Nelly M. Vega-Rivera, Alonso Fernández-Guasti, Gerardo RamÃrez-RodrÃguez, Erika Estrada-Camarena,