Subtypes in 22q11.2 deletion syndrome associated with behaviour and neurofacial morphology

► We identified two distinct phenotypes among children and adolescents with 22q11DS. ► Type-1: impaired verbal memory, lower intellectual and academic ability. ► Type-1: reduced total brain volume and presented with autism-spectrum traits. ► Type-2: more 22q11DS-typical face morphology. ► Type-2: executive function deficits, but high functioning cognition and behaviour.