Micellization and solubilization of a model hydrophobic drug nimesulide in aqueous salt solutions of Tetronic® T904

▶ The micellization of T904 in aqueous solutions and solubilization of nimesulide were examined. ▶ NMR and DLS were used to study the micellization at different temperatures and in the presence of salt. ▶ The solubilization increased with temperature and the drug solubilized in core region of micelles. ▶ It provides vital information that will enable the use of T904 as drug carrier or in drug releasing systems.