Biomimetic gelatin-octacalcium phosphate core-shell microspheres

► Gelatin microspheres coated with octacalcium phosphate. ► Functionalization of microspheres with calcium ions. ► Functionalization of microspheres with a bisphosphonate (alendronate). ► Calcium phosphate porous shell modulates gelatin and alendronate release. ► Biomimetic mineralization based on molecular recognition.