کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10435067 | 910808 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Development of a closed-loop J-T cryoablation device with a long cooling area and multiple expansion parts
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Development of a closed-loop J-T cryoablation device with a long cooling area and multiple expansion parts Development of a closed-loop J-T cryoablation device with a long cooling area and multiple expansion parts](/preview/png/10435067.png)
چکیده انگلیسی
Cryoablation is a surgical procedure used to freeze defective cells by inserting a low temperature probe into a human body to destroy malignant tissues. Miniaturized Joule-Thomson (J-T) refrigerators are often used to minimize the volume of the cooling device and reduce the destruction zone of normal tissue. The cooling effects of the existing probes are not uniformly generated along the longitudinal direction of the probe, which makes their applications less effective in surgeries of incompetent great saphenous veins (GSVs), where the target cells are distributed over a broad range. Long uniform refrigeration is required across the entire area of the probe to apply the same cooling effects. In this paper, a closed-loop J-T cryoablation probe was designed and fabricated to provide uniform refrigeration over a large area, with multiple expansion parts. Using flow boiling heat transfer, uniform cooling of a 200Â mm-long and 0.3Â mm thickness piece of target tissue was possible and simulated in a gelatin solution. The developed probe produced a greater than 53Â KÂ minâ1 cooling rate and the cooling temperature was below 253Â K to satisfy the required cell death conditions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Engineering & Physics - Volume 36, Issue 11, November 2014, Pages 1464-1472
Journal: Medical Engineering & Physics - Volume 36, Issue 11, November 2014, Pages 1464-1472
نویسندگان
Cheonkyu Lee, Seungwhan Baek, Jisung Lee, Gyuwan Hwang, Sangkwon Jeong, Sang Woo Park,