Hydrophobic-core PEGylated graft copolymer-stabilized nanoparticles composed of insoluble non-nucleoside reverse transcriptase inhibitors exhibit strong anti-HIV activity

Hydrophobic core protected graft copolymers (HC-PGC) such as MPEG-gPLL acylated with oleic acid, promote the formation of nanoparticles of water-insoluble benzophenone-uracyl non-nucleoside reverse transcriptase inhibitors after the co-lyophilization. These nanoparticles bind to the surface of HIV-1 infected effector cells and result in a high selectivity anti-HIV index because of their low toxicity.210