Survivin-targeted nanoparticles for pancreatic tumor imaging in mouse model

Whole body in vivo MRI showed a significant T2 signal reduction in tumors of mice injected with survivin targeted nanoparticles (A) but slight signal change in tumors of mice injected with non-targeted nanoparticles (B) or nonsense oligonucleotide nanoparticles (C). T2WI of pancreatic tumor was significantly lower than that of the precontrast and significant difference was also found in postcontrast T2 signals detected between 24 h and 40 h (D). No obvious differences were found in T2 signals in mice administrated with non-targeted nanoparticles and NSON-MNPs (D).248