Keywords: oligonucleotide antisense; ASO; antisense oligonucleotide; 2â²-MOE; 2â²-O-methoxyethyl; MB; molecular beacon; PS; pure sequence; DA; deamination marker; cPS; complementary pure sequence; Antisense oligonucleotide; Molecular beacon; Competitive hybridization; Deamination;
مقالات ISI oligonucleotide antisense (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: oligonucleotide antisense; ALS; Amyotrophic lateral sclerosis; Antisense oligonucleotide; Astrocyte; BMP; Bone morphogenetic protein; Motor neuron; Neuroinflammation; Non-cell autonomous; SOD1;
Keywords: oligonucleotide antisense; ASO; antisense oligonucleotide; ECM; extracellular matrix; DDR; discoidin domain receptor; FAP; fibroblast activation protein; HSC; hepatic stellate cell(s); MF; myofibroblast(s); Lox; lysyl oxidase; Loxl; lysyl oxidase-like; MMP; matrix metalloproteinase
Keywords: oligonucleotide antisense; Intrathecal; Drug delivery; Catheter; Antisense oligonucleotide; Rat; Cerebral spinal fluid; Thecal sack; Subarachnoid space;
Keywords: oligonucleotide antisense; ADT; androgen deprivation therapy; AR; androgen receptor; ASO; antisense oligonucleotide; CARN; castration-resistant Nkx3.1 expressing cells; CK; cytokeratin; CRPC; castration-resistant prostate cancer; DMBA; 7,12-dimethylbenz[a]anthracene; ECM; extracell
Keywords: oligonucleotide antisense; Ach; acetylcholine; ACL; anterior cruciate ligament; ACTH; adrenocorticotrophic hormone; AMP; adenosine monophosphate; AMPK; 5â²adenosine monophosphate-activated protein kinase; AS ODN; antisense oligonucleotide; BDNF; brain-derived neurotrophic factor;
Keywords: oligonucleotide antisense; HD; Huntington's disease; htt gene; huntingtin gene; HDACi; histone deacetylase inhibitors; RNAi; RNA interference; ASO; antisense oligonucleotide; Tgasei; transglutaminase inhibitors; Huntington's disease (HD); htt gene; Histone deacetylase inhibitors (H
Keywords: oligonucleotide antisense; Inflammatory bowel disease; Colonic macrophages; TNF-α; Antisense oligonucleotide; Targeting delivery
Keywords: oligonucleotide antisense; Cationic lipids; Cationic vesicles; Non-ionic surfactant vesicles; Antisense oligonucleotide; Antisense therapy; Gene delivery;
Keywords: oligonucleotide antisense; AAV1; adeno-associated virus serotype 1; ACC; American College of Cardiology; ACCELERATE; A Study of Evacetrapib in High-Risk Vascular Disease; ACCORD; Action to Control Cardiovascular Risk in Diabetes; ADA; American Diabetes Association; AMP; adenosine m
Keywords: oligonucleotide antisense; ALS; amyotrophic lateral sclerosis; ASO; antisense oligonucleotide; BBB; blood brain barrier; CREB; cyclic AMP response element binding protein; FDA; Food and Drug Administration; GSK-3; glycogen synthase kinase 3; HDAC; histone deacetylase; hnRNP A1; het
Keywords: oligonucleotide antisense; 2â²OMePS; 2â²-O-methyl phosphorothioate; 2â²MOE-PS; 2â²-O-methoxyethyl phosphorothioate; AON; antisense oligonucleotide; CPP; cell-penetrating peptide; DMD; Duchenne muscular dystrophy; PMO; phosphorodiamidate morpholino; PPMO; peptide-conjugated phos
Single-center experience with intrathecal administration of Nusinersen in children with spinal muscular atrophy type 1
Keywords: oligonucleotide antisense; Spinal muscular atrophy; Lumbar puncture; Nusinersen; ASO; antisense oligonucleotide; CHOP INTEND; Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders; CNS; central nervous system; CSF; cerebrospinal fluid; EAP; expanded access prog
Therapeutic silencing of FSP27 reduces the progression of atherosclerosis in Ldlr-/- mice
Keywords: oligonucleotide antisense; FSP27; Atherosclerosis; Obesity; Hypertriglyceridemia; Antisense therapy; ASO; antisense oligonucleotide; CVD; cardiovascular disease; CIDEC; cell death-inducing DFFA-like effector C; FSP27; fat-specific protein 27; gWAT; gonadal white adipose tissue; HDL
IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal
Keywords: oligonucleotide antisense; Arg1; Arginase 1; α-SMA; alpha-smooth muscle actin; ASO; antisense oligonucleotide; BW; body weight; CCL2; chemokine (C-C motif) ligand 2; CCl4; carbon tetrachloride; Col1a1; procollagen α1(I) transcript; DAPI; 4,6-diamidino-2-phenylindole; DKO; doubl
A randomized placebo-controlled phase 3 trial of an antisense oligonucleotide, drisapersen, in Duchenne muscular dystrophy
Keywords: oligonucleotide antisense; Duchenne muscular dystrophy; Drisapersen; Dystrophin; Antisense oligonucleotide; Exon skipping; six-minute walking distance;
Gene-based antiangiogenic applications for corneal neovascularization
Keywords: oligonucleotide antisense; cornea; neovascularization; angiogenesis; gene therapy; vascular endothelial growth factor; antisense oligonucleotide; miRNA;
Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice
Keywords: oligonucleotide antisense; Adult neurogenesis; Depression; ELAV-Like RBP; Hippocampal CA3 region; Sucrose preference test; Tail suspension test; aODN; antisense oligonucleotide; BDNF; brain-derived neurotrophic factor; CREB; cyclic-AMP response element-binding protein; DG; dentate
Angubindin-1 opens the blood-brain barrier in vivo for delivery of antisense oligonucleotide to the central nervous system
Keywords: oligonucleotide antisense; Antisense oligonucleotide; Angubindin-1; Blood-brain barrier; Tricellular tight junction; Angulin-1; Tricellulin;
Transdermal immunomodulation: Principles, advances and perspectives
Keywords: oligonucleotide antisense; AD; atopic dermatitis; AHR; airway hyper responsiveness; APCs; antigen-presenting cells; AS-ODN; antisense oligonucleotide; BCG; Bacillus Calmette-Guérin; CTLs; cytotoxic T cells; dDCs; dermal dendritic cells; DfE; Dermatophagoides farinae extract; EAE;
Effect of mipomersen on LDL-cholesterol in patients with severe LDL-hypercholesterolaemia and atherosclerosis treated by lipoprotein apheresis (The MICA-Study)
Keywords: oligonucleotide antisense; Lipoprotein; Familial hypercholesterolaemia; Antisense oligonucleotide; Apolipoprotein B;
The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice
Keywords: oligonucleotide antisense; AS-ODN; antisense oligonucleotide; DABK; des-Arginine9-bradykinin; DALBK; des-Arginine9-[Leucine8]-bradykinin; Iba-1; ionized calcium binding adaptor molecule; Mrgprs; Mas-related GPCR; MM-ODN; mismatch oligonucleotide; PAR-2 and PAR-4; proteinase-activat
Feature ArticleHER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug
Keywords: oligonucleotide antisense; HER2+ breast cancer; Polymer nanoconjugate; Trastuzumab mimetic peptide; 8-arm starPEG; Polymalic acid; AHNP; anti-HER2/neu peptide; Alexa; Alexa Fluor 680 (fluorescent dye); anti-TfR; anti-transferrin receptor; AON; antisense oligonucleotide; ATCC; Ameri
Silencing of the RNA-binding protein HuR attenuates hyperalgesia and motor disability in experimental autoimmune encephalomyelitis
Keywords: oligonucleotide antisense; Multiple sclerosis; Central nervous system; Neuropathic pain; HuR; Relapsing-remitting experimental autoimmune encephalomyelitis; aODN; antisense oligonucleotide; dODN; degenerate oligonucleotide; ELAV protein; embryonic lethal abnormal vision protein; GF
Alternative polyadenylation expands the mRNA isoform repertoire of human CD46
Keywords: oligonucleotide antisense; 5â²ss; 5â² splice site; 3â²RACE; 3â² Rapid Amplification of cDNA Ends; 3â²UTR; 3â² UnTranslated Region; APA; Alternative PolyAdenylation; ASO; AntiSense Oligonucleotide; CCP; Complement Control Protein; CD46; Cluster of Differentiation gene 46; CD46
Inhaled ENaC antisense oligonucleotide ameliorates cystic fibrosis-like lung disease in mice
Keywords: oligonucleotide antisense; Cystic fibrosis; ENaC; Antisense oligonucleotide; Aerosol;
Comparison of ambulatory capacity and disease progression of Duchenne muscular dystrophy subjects enrolled in the drisapersen DMD114673 study with a matched natural history cohort of subjects on daily corticosteroids
Keywords: oligonucleotide antisense; Duchenne muscular dystrophy; Antisense oligonucleotide; Comparative study; Exercise test; Dystrophin synthesis; Drug therapy;
Knocking down amygdalar PTP1B in diet-induced obese rats improves insulin signaling/action, decreases adiposity and may alter anxiety behavior
Keywords: oligonucleotide antisense; Amygdala; PTP1B; Insulin; Anxiety; Obesity; Akt; protein kinase B; ASO; antisense oligonucleotide; BAT; brown adipose tissue; CeA; central nucleus of the amygdala; CNS; central nervous system; EPM; elevated plus maze; ER; endoplasmatic reticulum; FI; food
Oligonucleotide-based pharmaceuticals: Non-clinical and clinical safety signals and non-clinical testing strategies
Keywords: oligonucleotide antisense; Antisense oligonucleotide; siRNA; Aptamer; Toxicity; Immunostimulation; Immunosuppression; Pharmacokinetics; Non-clinical; ALP; alkaline phosphatase; ALT; alanine aminotransferase; APTT; activated partial thromboplastin time; AST; aspartate aminotransfera
ReviewTargeting telomerase and telomeres to enhance ionizing radiation effects in in vitro and in vivo cancer models
Keywords: oligonucleotide antisense; TMM; telomere maintenance mechanism; T/TTC; telomere/telomerase targeting compound; G4; G-quadruplex; DSB; double strand break; ALT; alternative lengthening of telomeres; GBM; glioblastoma multiforme; AS-ODN; antisense oligonucleotide; TIF; telomere-induc
'Dual' peptidyl-oligonucleotide conjugates: Role of conformational flexibility in catalytic cleavage of RNA
Keywords: oligonucleotide antisense; RNA cleavage; Peptidyl-oligonucleotide conjugate; Supramolecular self-assembly; Hybridization; Conformation; ASO; antisense oligonucleotide; DC; dual conjugate; POC; peptidyl-oligonucleotide conjugate; FITC; fluorescein isothiocyanate; MALDI; matrix-assis
Clinical potential of oligonucleotide-based therapeutics in the respiratory system
Keywords: oligonucleotide antisense; AGO; Argonaute; ASO; antisense oligonucleotide; CCR3; C-C chemokine receptor 3; CPP; cell penetrating peptide; COPD; chronic obstructive pulmonary disease; CD; cluster designation; GMCSF; granulocyte monocyte-colony stimulating factor; IL; interleukin;
Exploring Splicing-Switching Molecules For Seckel Syndrome Therapy
Keywords: oligonucleotide antisense; (up to 6) Seckel syndrome-1; Exonic splicing silencer; modified U1snRNA; Antisense oligonucleotide; correction approaches;
Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility
Keywords: oligonucleotide antisense; AS; antisense oligonucleotide; GCS; glucosylceramide synthase; GCSI; glucosylceramide synthase inhibitor; GM3S; ganglioside GM3 synthase; IGF-1; insulin-like growth factor-1; IGF1R; insulin-like growth factor-1 receptor; IR; insulin receptor; M2D3; GM2/GD
Synthesis of antisense oligonucleotides containing acyclic alkynyl nucleoside analogs and their biophysical and biological properties
Keywords: oligonucleotide antisense; Acyclic nucleoside; Antisense oligonucleotide; Alkyne; RNase H; Thermal stability; Nuclease resistance;
Noninvasive delivery of oligonucleotide by penetratin-modified polyplexes to inhibit protein expression of intraocular tumor
Keywords: oligonucleotide antisense; Intraocular drug delivery; Antisense oligonucleotide; Penetratin; Polyplex; Luciferase expression;
Evolution, expression analysis, and functional verification of Catharanthus roseus RLK1-like kinase (CrRLK1L) family proteins in pear (Pyrus bretchneideri)
Keywords: oligonucleotide antisense; CrRLK1L; Catharanthus roseus RLK1-like kinases; RLKs; receptor-like kinases; PERKs; proline-rich extensin-like receptor-kinases; CRKs; cysteine-rich; LRR-RLKs; leucine-rich repeat RLKs; HERK1; HERCULES Receptor Kinase 1; RALFs; rapid alkalinization factor
Small Nucleolar Noncoding RNA SNORA23, Up-Regulated in Human Pancreatic Ductal Adenocarcinoma, Regulates Expression of Spectrin Repeat-Containing Nuclear Envelope 2 to Promote Growth and Metastasis of Xenograft Tumors in Mice
Keywords: oligonucleotide antisense; Pancreatic Cancer; Liver Metastasis; Oncogene; Non-Coding RNA; AmNA; amido-bridged nucleic acids; ASO; antisense oligonucleotide; cDNA; complementary DNA; CEA; carcinoembryonic antigen; HLMC; highly liver metastatic cell; IPMN; intraductal papillary mucin
Contributions of Japanese patients to development of antisense therapy for DMD
Keywords: oligonucleotide antisense; Duchenne muscular dystrophy; Becker muscular dystrophy; Exon skipping; Antisense oligonucleotide; Reading frame; Treatment
Pathological microRNAs in acute cardiovascular diseases and microRNA therapeutics
Keywords: oligonucleotide antisense; Non-protein coding RNAs; Antisense oligonucleotide; Hypertension
Synthesis of novel caged antisense oligonucleotides with fluorescence property
Keywords: oligonucleotide antisense; Caged compound; Thiochromone; Antisense oligonucleotide; Fluorescence; Luciferin-luciferase reaction;
Research ArticleIn vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides
Keywords: oligonucleotide antisense; HBV; hepatitis B virus; ASO; antisense oligonucleotide; HBsAg; hepatitis B surface antigen; HCC; hepatocellular carcinoma; NTCP; sodium taurocholate cotransporting polypeptide; cccDNA; circular covalently closed DNA; RT; reverse transcriptase; HBcAg; hepa
Increase of neurofilament-H protein in sensory neurons in antiretroviral neuropathy: Evidence for a neuroprotective response mediated by the RNA-binding protein HuD
Keywords: oligonucleotide antisense; aODN; antisense oligonucleotide; BDNF; brain derived neurotrophic factor; ddC; 2⿲,3⿲-dideoxycitidine; DMSO; dimethylsulfoxide; DRG; dorsal root ganglia; i.p.; intraperitoneal; i.t.; intrathecal; LFB; luxol fast blue; NF-L; neurofilament light; NF-M; n
Integrated analysis of the prostate cancer small-nucleolar transcriptome reveals SNORA55 as a driver of prostate cancer progression
Keywords: oligonucleotide antisense; Prostate cancer; SNORA55; Non-coding RNAs; Patient-derived xenograft; Next generation sequencing; Antisense oligonucleotide;
Osmolality of antisense oligonucleotide parenteral formulations: Implications on counterion dissociation and recommended osmometry techniques
Keywords: oligonucleotide antisense; Osmolality; Osmometry; Counterion dissociation; Antisense oligonucleotide;
Oral delivery of macromolecular drugs: Where we are after almost 100Â years of attempts
Keywords: oligonucleotide antisense; ADH; anti-diuretic hormone; AON; antisense oligonucleotide; 5-CNAC; N-(5-chlorosalicyloyl)-8-aminocaprylic acid; EDTA; ethylenediaminetetraacetate; FDA; Food and Drug Administration; GC C; guanylyl cyclase C; GI; gastrointestinal; GLP-1; glucagon-like pep
Evaluation of the effects of chemically different linkers on hepatic accumulations, cell tropism and gene silencing ability of cholesterol-conjugated antisense oligonucleotides
Keywords: oligonucleotide antisense; Cholesterol conjugation; Linkage; Antisense oligonucleotide;
Survivin-targeted nanoparticles for pancreatic tumor imaging in mouse model
Keywords: oligonucleotide antisense; Survivin; Antisense oligonucleotide; Magnetic nanoparticles; Pancreatic cancer; Magnetic resonance imaging;
Targeting PCSK9 as a promising new mechanism for lowering low-density lipoprotein cholesterol
Keywords: oligonucleotide antisense; ALT; alanine transaminase; ASO; antisense oligonucleotide; apoB; apolipoprotein B; CVD; cardiovascular disease; EGF; epidermal growth factor; LDL-C; low-density lipoprotein cholesterol; MTP; microsomal triglyceride transfer protein; PCSK9; proprotein conv
XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides
Keywords: oligonucleotide antisense; Antisense oligonucleotide; RNase H1; Exoribonuclease; RNA degradation; siRNA;