دانلود مقالات ISI درباره oligonucleotide antisense + ترجمه فارسی

XRN2 is required for the degradation of target RNAs by RNase H1-dependent antisense oligonucleotides

Keywords: oligonucleotide antisense; Antisense oligonucleotide; RNase H1; Exoribonuclease; RNA degradation; siRNA;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Bioconjugates for targeted delivery of therapeutic oligonucleotides

Keywords: oligonucleotide antisense; ASO; antisense oligonucleotide; CDM; carboxylated dimethyl maleic acid; CPP; cell penetrating peptide; DPC; dynamic polyconjugate; ED50; median effective dose; GalNAc; N-acetylgalactosamine; LNP; lipid nanoparticle; NP; nanoparticle; ON; oligonucleotide;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Rescue of gene-expression changes in an induced mouse model of spinal muscular atrophy by an antisense oligonucleotide that promotes inclusion of SMN2 exon 7

Keywords: oligonucleotide antisense; ASO; antisense oligonucleotide; Cdkn1A; cyclin-dependent kinase inhibitor 1A; cDNA; complementary DNA; FDR; false discovery rate; FUS; fused in sarcoma; Hist1H1C; histone cluster 1, H1C; ICV; intracerebroventricular; ISS; intronic splicing silencer; P; po

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy

Keywords: oligonucleotide antisense; aODN; antisense oligonucleotide; CaMKII; Ca2 +-calmodulin-dependent kinase II; ddC; 2′,3′-dideoxycitidine; dODN; degenerate oligonucleotide; ELAV protein; embryonic lethal abnormal vision protein; HIV-SN; HIV-associated sensory neuropathy; i.p.; intr

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension

Keywords: oligonucleotide antisense; Lung delivery; Lipid nanoparticle; Antisense oligonucleotide; Pulmonary hypertension; MicroRNA-145; Sugen5416/hypoxia;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

Protein tyrosine phosphatase 1B (PTP1B): A key regulator and therapeutic target in liver diseases

Keywords: oligonucleotide antisense; PTKs; protein tyrosine kinases; PTPs; protein tyrosine phosphatases; PTP1B; protein tyrosine phosphatase 1B; NAFLD; non-alcoholic fatty liver disease; HCC; hepatocellular carcinoma; DSPs; dual specificity phosphatases; LMW; low molecular weight; RPTPs; tr

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2015 سفارش ترجمه

Cardiac myosin-binding protein C (MYBPC3) in cardiac pathophysiology

Keywords: oligonucleotide antisense; AAV; adeno-associated virus; AON; antisense oligonucleotide; bp; base pair; Ca2+;  calcium; CaMKII; Ca2+/calmodulin-dependent kinase II; Chr; chromosome; CK2; casein kinase 2; CMH4; hypertrophic cardiomyopathy, locus 4; cMyBP-C; cardiac myosin-binding pr

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

A Randomised Phase 2 Study Combining LY2181308 Sodium (Survivin Antisense Oligonucleotide) with First-line Docetaxel/Prednisone in Patients with Castration-resistant Prostate Cancer

Keywords: oligonucleotide antisense; Antisense oligonucleotide; Castration-resistant prostate cancer; Docetaxel; Survivin; LY2181308;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Functional regulation of RNA-induced silencing complex by photoreactive oligonucleotides

Keywords: oligonucleotide antisense; Antisense oligonucleotide; microRNA; RISC; Psoralen; Photoreactive;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Aib-containing peptide analogs: Cellular uptake and utilization in oligonucleotide delivery

Keywords: oligonucleotide antisense; α-Aminoisobutyric acid (Aib); α-Helix; Cell-penetrating peptide (CPP); Antisense oligonucleotide;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

c-Fos: An AP-1 transcription factor with an additional cytoplasmic, non-genomic lipid synthesis activation capacity

Keywords: oligonucleotide antisense; PC; phosphatidylcholine; PE; phosphatidylethanolamine; PtdIns; phosphatidylinositol; PS; phosphatidylserine; ER; endoplasmic reticulum; PSS; phosphatidylserine synthase; CCT; CTP:phosphocholine cytidylyltransferase; GPAT; Acyl-CoA:glycerol-3-phosphate acy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Liver histology during Mipomersen therapy for severe hypercholesterolemia

Keywords: oligonucleotide antisense; Liver; VLDL; LDL; Apolipoprotein B; Cholesterol; Triglycerides; Fibrosis; Inflammation; Nonalcoholic fatty liver disease; Steatohepatitis; Antisense oligonucleotide;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Locked nucleic acid antisense inhibitor targeting apolipoprotein C-III efficiently and preferentially removes triglyceride from large very low-density lipoprotein particles in murine plasma

Keywords: oligonucleotide antisense; Hyperlipidemia; Antisense oligonucleotide; Synthetic nucleic acid; Bridged nucleic acids; Locked nucleic acids; Apolipoprotein C-III

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Requirement of the expression of 3-phosphoglycerate dehydrogenase for traversing S phase in murine T lymphocytes following immobilized anti-CD3 activation

Keywords: oligonucleotide antisense; l-Serine biosynthesis; The phosphorylated pathway; PHGDH; T cell activation; IL-2R signaling; S phase; Antisense oligonucleotide

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

The systemic administration of an anti-miRNA oligonucleotide encapsulated pH-sensitive liposome results in reduced level of hepatic microRNA-122 in mice

Keywords: oligonucleotide antisense; miRNA; Antisense oligonucleotide; Drug delivery system; Liposomes; miR-122;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Widespread genome transcription: New possibilities for RNA therapies

Keywords: oligonucleotide antisense; Aβ; amyloid beta; AGO; argonaute; AON; antisense oligonucleotide; AS RNA; antisense RNA; ATL; adult T-cell leukemia; EBOV; Ebola virus; eRNA; enhancer RNA; ES; embryonic stem; HBZ; HTLV-1 basic leucine zipper factor; HTLV-1; human T-cell leukemia virus t

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

PKC-mediated HuD-GAP43 pathway activation in a mouse model of antiretroviral painful neuropathy

Keywords: oligonucleotide antisense; aODN; antisense oligonucleotide; ATF3; activating transcription factor; ddC; 2′,3′-dideoxycitidine; dODN; degenerate oligonucleotide; ELAV protein; embryonic lethal abnormal vision protein; GAP-43; growth-associated protein; HAART; highly active antir

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Gα12gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation

Keywords: oligonucleotide antisense; AP-1; activator protein-1; ASO; antisense oligonucleotide; ChIP; chromatin immunoprecipitation; FOXO1; forkhead box O1; Gα12QL; active mutant of Gα12; GPCR; G protein-coupled receptor; HCC; hepatocellular carcinoma; MDM2; murine double minute 2 homolog;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy

Keywords: oligonucleotide antisense; Ischemic arrhythmias; MicroRNA-1; Liposomes; Antisense oligonucleotide; Anti-cTnI antibody; In vivo imaging;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Regular ArticleThe RNA-binding protein HuD promotes spinal GAP43 overexpression in antiretroviral-induced neuropathy

Keywords: oligonucleotide antisense; aODN; antisense oligonucleotide; ART; antiretroviral therapy; ATF3; activating transcription factor 3; ddC; 2′,3′-dideoxycytidine; dODN; degenerate oligonucleotide; DRG; dorsal root ganglia; ELAV protein; embryonic lethal abnormal vision protein; GAP4

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Antisense oligonucleotides on neurobehavior, respiratory, and cardiovascular function, and hERG channel current studies

Keywords: oligonucleotide antisense; ASO; Antisense Oligonucleotide; CNS; Central Nervous System; ECG; Electrocardiography; FOB; Functional Observatory Battery; GLP; Good Laboratory Practice; hERG; Human Ether-a-go-go related gene; ICH; International Conference on Harmonisation; IC50; The ha

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Emerging LDL therapies: Mipomersen-antisense oligonucleotide therapy in the management of hypercholesterolemia

Keywords: oligonucleotide antisense; Antisense oligonucleotide; Apolipoprotein B; Familial hypercholesterolemia; Low-density lipoprotein cholesterol; Mipomersen;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Dynamics of human telomerase RNA structure revealed by antisense oligonucleotide technique

Keywords: oligonucleotide antisense; Telomerase; RNA interference; Antisense oligonucleotide;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Ataxin-3 protein modification as a treatment strategy for spinocerebellar ataxia type 3: Removal of the CAG containing exon

Keywords: oligonucleotide antisense; SCA3; spinocerebellar ataxia type 3; MJD; Machado-Joseph disease; PolyQ; polyglutamine; ATXN3; ataxin-3; UIMs; ubiquitin interacting motifs; RNAi; RNA interference; AON; antisense oligonucleotide; SNP; single nucleotide polymorphism; DMD; Duchenne muscu

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting long non-coding RNAs in cancers: Progress and prospects

Keywords: oligonucleotide antisense; ANRIL; antisense non-coding RNA in the INK4 locus; ATRA; all-trans retinoic acid; ASO; antisense oligonucleotide; CRC; colorectal carcinoma; CREB; cAMP-responsive element binding protein; DM1; myotonic dystrophy type 1; DsRNA; double-stranded RNA; EMT; ep

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Mechanisms of allergy and clinical immunologyMicroRNA-17/20a/106a modulate macrophage inflammatory responses through targeting signal-regulatory protein α

Keywords: oligonucleotide antisense; Signal-regulatory protein α; microRNA; macrophage; inflammatory response; ASO; Antisense oligonucleotide; FITC; Fluorescein isothiocyanate; GAPDH; Glyceraldehyde-3-phosphate dehydrogenase; ITIM; Immunoreceptor tyrosine-based inhibitory motif; miRNA; Micr

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

Antisense directed against PS-1 gene decreases brain oxidative markers in aged senescence accelerated mice (SAMP8) and reverses learning and memory impairment: A proteomics study

Keywords: oligonucleotide antisense; AD; Alzheimer's disease; MCI; mild cognitive impairment; Aβ; amyloid β-peptide; FAD; familial Alzheimer's disease; NFT; intracellular neurofibrillary tangles; APP; amyloid precursor protein; PS-1; presenilin-1; PS-2; presenilin-2; AO; antisense oligonuc

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2013 سفارش ترجمه

Learning-facilitated long-term depression requires activation of the immediate early gene, c-fos, and is transcription dependent

Keywords: oligonucleotide antisense; Antisense oligonucleotide; LTD; Synaptic plasticity; Hippocampus; Immediate early gene; Actinomycin-D

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

New LDL-Cholesterol Lowering Therapies: Pharmacology, Clinical Trials, and Relevance to Acute Coronary Syndromes

Keywords: oligonucleotide antisense; antisense oligonucleotide; dyslipidemia; hypercholesterolemia; monoclonal antibody; myocardial infarction; unstable angina

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2013 سفارش ترجمه

Antisense oligonucleotide corrects splice abnormality in hereditary myopathy with lactic acidosis

Keywords: oligonucleotide antisense; Metabolic myopathy; Intronic mutation; Cryptic exon; Antisense oligonucleotide; Intronic splicing silencer

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

The effect of targeted delivery of anti-TNF-α oligonucleotide into CD169+ macrophages on disease progression in lupus-prone MRL/lpr mice

Keywords: oligonucleotide antisense; Systemic lupus erythematosus; TNF-α; CD169+ macrophage; Antisense oligonucleotide; Drug delivery

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Phase I/II Trial of Custirsen (OGX-011), an Inhibitor of Clusterin, in Combination with a Gemcitabine and Platinum Regimen in Patients with Previously Untreated Advanced Non-small Cell Lung Cancer

Keywords: oligonucleotide antisense; Advanced NSCLC; Antisense oligonucleotide; Novel therapeutics; Chemotherapy; Biomarker

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity

Keywords: oligonucleotide antisense; Nucleic acid; Antisense oligonucleotide; Docosanoic acid; Albumin; Polymeric micelle; Fatty acid

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Farnesoid X Receptor Protects Hepatocytes From Injury by Repressing miR-199a-3p, Which Increases Levels of LKB1

Keywords: oligonucleotide antisense; Nuclear Receptor; Noncoding RNA; Mitochondrial Protection; Fibrotic Liver Injury; AA; arachidonic acid; AMPK; AMP-activated protein kinase; ASO; antisense oligonucleotide; CAB39; calcium binding protein 39; CDCA; chenodeoxycholic acid; DCFH-DA; 2′,7′-

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Association of Long-term Administration of the Survivin mRNA-Targeted Antisense Oligonucleotide LY2181308 With Reversible Kidney Injury in a Patient With Metastatic Melanoma

Keywords: oligonucleotide antisense; Antisense oligonucleotide; survivin; kidney injury;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Combination of vascular endothelial growth factor antisense oligonucleotide therapy and radiotherapy increases the curative effects against maxillofacial VX2 tumors in rabbits

Keywords: oligonucleotide antisense; Vascular endothelial growth factor; Antisense oligonucleotide; Radiotherapy; VX2 tumor; Rabbit

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line

Keywords: oligonucleotide antisense; ASO; antisense oligonucleotide; cDNA; complementary DNA; EGFP; enhanced green fluorescent protein; FN1; fibronectin1; GAPDH; glyceraldehyde phosphate dehydrogenase; HRP; horseradish peroxidase; miR-1; microRNA-1; miRNA; microRNA; MTT; 3-(4,5-dimethylthiaz

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Antisense PCR: A simple and robust method for performing nested single-tube PCR

Keywords: oligonucleotide antisense; Nested PCR; Single-tube amplification; Antisense oligonucleotide; Nonspecific amplification; Multiplex PCR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Nanomedicine: Novel approaches in human and veterinary therapeutics

Keywords: oligonucleotide antisense; AS-ON; antisense oligonucleotide; AZT; azidothymidine; CMC; critical micelle concentration; CP; calcium phosphate; CTB; cholera toxin B subunit; CYP; cytochrome P450; DCs; dendritic cell; DEAE; diethylaminoethyl; FURD; 5-fluorouridine; GALT; gut-associate

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2011 سفارش ترجمه

Stepwise synthesis of oligonucleotide–peptide conjugates containing guanidinium and lipophilic groups in their 3′-termini

Keywords: oligonucleotide antisense; ODN–peptide conjugates; Dickerson–Drew dodecamer; Luciferase; Postsynthetic guanidinylation reaction; Ureas; Antisense oligonucleotide; Phosphorothioates

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Gene therapy for muscle disease

Keywords: oligonucleotide antisense; Dystrophin; Duchenne muscular dystrophy (DMD); Recombinant adenoassociated viral (AAV); Exon skipping; Antisense oligonucleotide; Gene therapy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Novel therapies and new targets of treatment for familial hypercholesterolemia

Keywords: oligonucleotide antisense; Antisense oligonucleotide; Apolipoprotein B; Familial hypercholesterolemia; LDL cholesterol; MTP inhibitor; Thyroid hormone analogue

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

The alkyl-connected 2-amino-6-vinylpurine (AVP) crosslinking agent for improved selectivity to the cytosine base in RNA

Keywords: oligonucleotide antisense; Antisense oligonucleotide; Crosslink; RNA; Base selectivity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Mixed backbone antisense glucosylceramide synthase oligonucleotide (MBO-asGCS) loaded solid lipid nanoparticles: In vitro characterization and reversal of multidrug resistance in NCI/ADR-RES cells

Keywords: oligonucleotide antisense; Solid lipid nanoparticle; Antisense oligonucleotide; Stability; Cancer therapy; Drug delivery;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Specific down regulation of 3T3-L1 adipocyte differentiation by cell-permeable antisense HIF1α-oligonucleotide

Keywords: oligonucleotide antisense; Angiogenesis; Antisense oligonucleotide; Hypoxia inducible factor 1α; Low molecular weight protamine; Obesity;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

The roles of the α1-adrenergic receptor subtypes in rat embryonic implantation

Keywords: oligonucleotide antisense; α1-adrenergic receptors; rat; implantation; antisense oligonucleotide

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

A Phase I/II Study of GTI-2040 Plus Docetaxel as Second-Line Treatment in Advanced Non-small Cell Lung Cancer: A Study of the PMH Phase II Consortium

Keywords: oligonucleotide antisense; Antisense oligonucleotide; Lung cancer; Second-line; Docetaxel; GTI-2040; Ribonucleotide reductase; R2 subunit

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Effect of dose and plasma concentration on liver uptake and pharmacologic activity of a 2′-methoxyethyl modified chimeric antisense oligonucleotide targeting PTEN

Keywords: oligonucleotide antisense; Pharmacokinetics; Antisense oligonucleotide; mRNA; Pharmacodynamics; Liver

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2009 سفارش ترجمه

Volume-activated chloride channels contribute to cell-cycle-dependent regulation of HeLa cell migration

Keywords: oligonucleotide antisense; Chloride channels; Cell cycle; Cell migration; ClC-3; Antisense oligonucleotide

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Preparation and evaluation of cholesteryl PAMAM dendrimers as nano delivery agents for antisense oligonucleotides

Keywords: oligonucleotide antisense; Dendrimer; Cholesterol; Antisense oligonucleotide; Delivery

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه