Bioactive silica nanoparticles reverse age-associated bone loss in mice

Weekly administration of osteogenic spherical silica shell, cobalt ferrite metal core, pegylated nanoparticles (NP1-MNP-PEG) to aged mice in vivo significantly alleviates and reverses age-associated loss of bone mineral density and trabecular bone volume, by promoting new bone formation. Silica nanoparticles may have clinical potential for use as a novel anti-osteoporotic therapeutic.163