VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor

MRI is one of the most powerful tools for tumor diagnostics, but still it has some limitations, which mostly associated with poor contrast between normal and pathological tissues. One approach to improve contrast in MRI is the use of contrast agent, such as magnetic iron oxide nanoparticles. In this study, we present VEGF-targeted iron oxide nanoparticles that act as glioma targeted T2 contrast agent, which can visualize brain tumor by MRI 24 h post intravenous injection.154