Protamine-carboxymethyl cellulose magnetic nanocapsules for enhanced delivery of anticancer drugs against drug resistant cancers

Schematic diagram SD2. Cellular uptake of Dox-MNC in drug resistant cells. (1) Transferrin protein (Tfp) attaches with Fe3O4 particles (Tf-Fe) on the MNC surface and binds with transferrin receptor protein (TfRe) in the cell membrane. (2) Tf-Fe-TfRe complex getting internalized by clathrin mediated endocytosis (CME). (3) Tf-Fe-TfRe getting dissociated in late endosome. (4) Dox releasing from NCp at cytoplasm and (5) Dox entering into nucleus. In the right side of the figure, cells treated with free Dox efflux out the drug by MDR efflux pumps.