Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation

The figure summarizes in vitro and in vivo studies in this publication that show the feasibility of intransal delivery of tumor necrosis factor-alpha (TNFα) gene silencing small interfering RNA (siRNA) administered using cationic oil-in-water nanoemulsion formulations in a lipopolysaccharide-induced neuro-inflammation model established in Sprague-Dawley rats.240