Superparamagnetic iron-oxide nanoparticles mPEG350- and mPEG2000-coated: cell uptake and biocompatibility evaluation

In this study a nanostructured superparamagnetic iron oxide carrier was synthesized and characterized presenting controlled mean diameter, high crystallinity and excellent magnetic properties for biomedical application purpose. According to in vitro results, the nanoparticulated system showed a high internalization capability in different cell lines. However, the highest dose administrated in vivo, in an acute test indicated liver and kidney damage in mice.187