Highly aligned nanocomposite scaffolds by electrospinning and electrospraying for neural tissue regeneration

A novel tissue engineered neural nanocomposite scaffold was created by integrating electrospinning and electrospraying techniques. The nanocomposite scaffold has highly aligned electrospun poly-ε-caprolactone microfibers and electrosprayed bioactive factor loaded poly (d, l-lactide-co-glycolide) nanospheres. Results demonstrated that the aligned microfibrous topography can successfully direct neurite outgrowth and extension. More importantly, the introduction of novel bioactive factor-loaded nanospheres can create a cell favorable nano surface topography and keep a sustained release of bioactive factors for promoted neural cell growth and axonal extension.307