G5 PAMAM dendrimer versus liposome: A comparison study on the in vitro transepithelial transport and in vivo oral absorption of simvastatin

The findings of this study indicate that both SMV/G5-NH2 complexes and SMV-liposomes are effective in promoting the in vitro transport and in vivo oral bioavailability of SMV with the liposomes being more effective than the G5-NH2. G5-NH2 complexes improve oral bioavailability of SMV due to the combined effects of an increase in solubility of SMV, inhibition of P-gp, and interruption of TJ. SMV-liposomes are more significant in improvement of solubility, encapsulation, clathrin-medicated transport and oral absorption of SMV.138