Citrem modulates internal nanostructure of glyceryl monooleate dispersions and bypasses complement activation: Towards development of safe tunable intravenous lipid nanocarriers

Towards design of hemocompatible lipid-based drug delivery systems: To realize the potential of lyotropic non-lamellar liquid crystalline (LLC) aqueous nanodispersions as intravenous drug carriers, their compatibility in human blood must be proven. We show that stabilization of LLC aqueous dispersions with citrem modulates the internal nanostructure, and overcomes hemolysis as well as complement activation, which is the first line of the body's defense against particulate intruders.174