کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10436020 | 911022 | 2012 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice Assessment of β-lapachone loaded in lecithin-chitosan nanoparticles for the topical treatment of cutaneous leishmaniasis in L. major infected BALB/c mice](/preview/png/10436020.png)
چکیده انگلیسی
After demonstrating the ex vivo performance of lecithin-chitosan NP for enhancing the penetration and dermal accumulation of the poorly soluble drug β-lapachone, the efficacy of the treatment was topically assayed in L. major infected BALB/c mice. Despite the treatment did not influence the parasite burden, it down-regulated IL-1β and COX-2 and reduced the neutrophil infiltrate, thus decreasing the necrosis and size of the skin lesion. Our finding offers a new approach of utility for weakening skin damage in cutaneous leishmaniasis lesions.156
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 11, Issue 8, November 2015, Pages 2003-2012
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 11, Issue 8, November 2015, Pages 2003-2012
نویسندگان
Esther PhD, Juana MD, Esther PhD, Iosune MD, Maria PhD, Carmen PhD, Juan Manuel PhD, Socorro PhD,