Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape

The effect of physicochemical characteristics especially particle shape on mesoporous silica nanoparticles (MSNs), as an efficient oral drug carrier, on their in vivo behaviors has been paid little attention. In this study, we synthesized three differently shaped mesoporous silica nanoparticles (MSNs) with aspect ratios of 1, 1.75 and 5, and systematically researched their in vivo distribution, excretion and toxicity after oral administration.101