In vivo toxicity assessment of non-cadmium quantum dots in BALB/c mice

The long term in vivo toxicity of InP/ZnS QDs in BALB/c mice was systematically evaluated in this study. The intact QDs predominantly accumulated in the spleen and liver, and indium element from injected QDs remained in major organs over 84 days. No changes in body weight, hematological and biochemical analysis and histological analysis were observed, thereby suggesting that InP/ZnS QDs can serve as optical probes for specific clinical applications when an optimized dosage is employed.115