Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair

Silver nanoparticles were demonstrated to play an important role in different stages of Achilles tendon healing. Silver nanoparticles were shown to be anti-inflammatory and reduced tumor necrosis factor α in this study. They also promoted the expression of fibromodulin which is a proteoglycan essential for the fibrillogenesis of collagen. Better collagen alignment was resulted with silver nanoparticles treatment and therefore improved functional outcome of the repaired tendon. Our study suggested a potential alternative treatment for this problematic area in modern medicine.84