In vivo biodistribution of platinum-based drugs encapsulated into multi-walled carbon nanotubes

The chemotherapeutic drug cisplatin or its derivative platinum(IV) complex were entrapped inside functionalized-multi-walled carbon nanotubes and then intravenously injected into mice to investigate the influence of the nanotubes on the biodistribution of Pt-based molecules. The amino-functionalized nanotubes significantly enhanced the accumulation of Pt(IV) sample in the lungs, and reduced both kidney and liver accumulation.256