Peptide functionalized polyhydroxyalkanoate nanofibrous scaffolds enhance Schwann cells activity

In this study, electrospun composite scaffolds combining poly (3-hydroxybutyrate) (PHB) and poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) were biofunctionalized with different biomolecules to mimic naturally occurring ECM motifs for nerve regeneration. The results of this study demonstrated that aligned PHB/PHBV electrospun nanofibers could find potential use as scaffolds for nerve tissue engineering applications and that the presence of ECM derived peptides in the surface nanofibers improves attachment, growth and differentiation of SCs.75