High loading of hydrophilic/hydrophobic doxorubicin into polyphosphazene polymersome for breast cancer therapy

Polymersomes were created by self-assembly of amphiphilic PEGylated polyphosphazene (PEP) in an aqueous solution to effectively load chemotherapeutic agent doxorubicin in its hydrophilic form (DH) or hydrophobic form (D). In vitro and in vivo studies revealed the distinguishable performance relevant to the water solubility of drug as well as the drug loading system.148