Association of serotonin transporter gene polymorphism with nicotine dependence: no evidence for an interaction with trait neuroticism

These data suggest that 5HTT genotype is associated with nicotine dependence independently of any association between this gene and trait neuroticism that may modulate smoking behaviour. We failed to replicate the finding of a moderating influence of 5HTT genotype on the association between neuroticism and nicotine dependence.