کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10455616 921235 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Young adult female fragile X premutation carriers show age- and genetically-modulated cognitive impairments
چکیده انگلیسی
The high frequency of the fragile X premutation in the general population and its emerging neurocognitive implications highlight the need to investigate the effects of the premutation on lifespan cognitive development. Until recently, cognitive function in fragile X premutation carriers (fXPCs) was presumed to be unaffected by the mutation. Here we show that young adult female fXPCs show subtle, yet significant, age- and FMR1 gene mutation-modulated cognitive impairments as tested by a quantitative magnitude comparison task. Our results begin to define the neurocognitive endophenotype associated with the premutation in adults, who are at risk for developing a neurodegenerative disorder associated with the fragile X premutation. Results from the present study may potentially be applied toward the design of early interventions wherein we might be able to target premutation carriers most at risk for degeneration for preventive treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Cognition - Volume 75, Issue 3, April 2011, Pages 255-260
نویسندگان
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