A model of amygdala-hippocampal-prefrontal interaction in fear conditioning and extinction in animals

► We present a systems-level model of fear conditioning. ► We simulate function of the amygdala, hippocampus, and prefrontal cortex. ► The model accounts fear conditioning data, including acquisition and extinction. ► Our model also assumes that fear extinction involves inhibitory CS-no US learning. ► Our model assumes two subregions within the amygdala that separately subserve fear acquisition and extinction.