Brain interleukin-15 in neuroinflammation and behavior

► Cerebral IL15 modulates neurotransmission and facilitates hippocampal memory. ► IL15 signaling benefits mood stability, prevents depressive-like behavior and apathy. ► IL15 contributes to thermoregulation in the hypothalamus and curtails hyperthermia. ► Neuroinflammation upregulates cerebral IL15 receptors to limit metabolic consequences.