کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10461525 | 924515 | 2011 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional connectivity and cholinergic modulation in auditory cortex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Although it is known that primary auditory cortex (A1) contributes to the processing and perception of sound, its precise functions and the underlying mechanisms are not well understood. Recent studies point to a remarkably broad spectral range of largely subthreshold inputs to individual neurons in A1 - seemingly encompassing, in some cases, the entire audible spectrum - as evidence for potential, and potentially unique, cortical functions. We have proposed a general mechanism for spectral integration by which information converges on neurons in A1 via a combination of thalamocortical pathways and intracortical long-distance, “horizontal”, pathways. Here, this proposal is briefly reviewed and updated with results from multiple laboratories. Since spectral integration in A1 is dynamically regulated, we also show how one regulatory mechanism - modulation by the neurotransmitter acetylcholine (ACh) - could act within the hypothesized framework to alter integration in single neurons. The results of these studies promote a cellular understanding of information processing in A1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 35, Issue 10, November 2011, Pages 2058-2063
Journal: Neuroscience & Biobehavioral Reviews - Volume 35, Issue 10, November 2011, Pages 2058-2063
نویسندگان
Raju Metherate,