Revisiting the controversial role of salsolinol in the neurobiological effects of ethanol: Old and new vistas

► Salsolinol is present in brain at very low concentrations. ► Its concentration tend to be higher in brain regions with abundant DA content. ► In most studies, chronic ethanol exposure increments salsolinol brain levels. ► It is not fully demonstrated that acute ethanol increases salsolinol brain levels. ► Salsolinol evokes neurobiological responses related to the DA neurons activation.