کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10461603 | 924523 | 2011 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice Altering BDNF expression by genetics and/or environment: Impact for emotional and depression-like behaviour in laboratory mice](/preview/png/10461603.png)
چکیده انگلیسی
The present review summarizes recent findings in BDNF-mutant mice, which have been controversially discussed as models of depression and anxiety. It furthermore illustrates the potential of environment to serve as naturalistic stressor with the potential to modulate the phenotype in wildtype and mutant mice. Moreover, environment may exert protective effects by regulating BDNF levels as attributed to “environmental enrichment”. The effect of this beneficial condition will also be discussed with regard to probable “curative/therapeutic” approaches.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 35, Issue 3, January 2011, Pages 599-611
Journal: Neuroscience & Biobehavioral Reviews - Volume 35, Issue 3, January 2011, Pages 599-611
نویسندگان
Sabine Chourbaji, Christiane Brandwein, Peter Gass,