Systematic review: Pharmacological treatment of tic disorders - Efficacy of antipsychotic and alpha-2 adrenergic agonist agents

► Both antipsychotics and alpha-2 agonists have efficacy in reducing tic symptoms. ► Head-to-head trials of antipsychotics suggest they are roughly equivalent in efficacy. ► Alpha-2 Agonists appear most effective in treating tics in children with ADHD.