کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10463269 925111 2013 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopamine reverses reward insensitivity in apathy following globus pallidus lesions
ترجمه فارسی عنوان
دوپامین بی حساسیت پاداش را در بی تفاوتی پس از ضایعات گلوبال پالیدویی متوقف می کند
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی
Here we present a very rare case with profound apathy following bilateral, focal lesions of the basal ganglia, with globus pallidus regions that connect with orbitofrontal (OFC) and ventromedial prefrontal cortex (VMPFC) particularly affected. Using two measures of oculomotor decision-making we show that apathy in this individual was associated with reward insensitivity. However, reward sensitivity could be established partially with levodopa and more effectively with a dopamine receptor agonist. Concomitantly, there was an improvement in the patient's clinical state, with reduced apathy, greater motivation and increased social interactions. These findings provide a model system to study a key neuropsychiatric disorder. They demonstrate that reward insensitivity associated with basal ganglia dysfunction might be an important component of apathy that can be reversed by dopaminergic modulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cortex - Volume 49, Issue 5, May 2013, Pages 1292-1303
نویسندگان
, , , , , , ,