Time, action and psychosis: Using subjective time to investigate the effects of ketamine on sense of agency

► Voluntary actions and outcomes are bound together in subjective time. ► This binding depends partly on advance prediction, something that is disrupted in schizophrenia. ► Administering ketamine, a drug model of psychosis, to healthy adults disrupted prediction. ► This effect closely resembled previous data from prodromal patients. ► Results are discussed in terms of (a) models of delusion formation and (b) the relationship between time and agency.