Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study

► Cognition and beta-amyloid (PiB PET) in preclinical phase of Alzheimer's disease. ► Impact of age, gender, education, APOE, and memory complaint. ► PiB positive females have worse memory and visuospatial performance. ► No effect of PiB in males. ► Overall, minimal effect of beta-amyloid at this phase.